A subset of participants underwent fetal echocardiogram after 2 weeks on juice with no evidence of ductal constriction. Ninety-nine mothers and their eligible fetuses ( n = 103) were recruited from Brigham and Women’s Hospital and randomly assigned to 8 oz pomegranate ( n = 56) or placebo ( n = 47) juice to be consumed daily from enrollment to delivery. This double-blind exploratory randomized controlled trial further investigates the impact of maternal pomegranate juice intake on brain structure and injury in a second cohort of IUGR pregnancies diagnosed at 24–34 weeks’ gestation. We recently reported altered white matter microstructure and functional connectivity in the infant brain following in utero pomegranate juice exposure in pregnancies with intrauterine growth restriction (IUGR). Animal studies have demonstrated the therapeutic potential of polyphenol-rich pomegranate juice.
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